Schizencephaly: Psychosis, A Rare Manifestation

Aloysius A, Seed HF, Thong KS


Schizencephaly is an uncommon congenital malformation of the central nervous system which affects the development of the cerebral cortex. It is defined as the gray matter lined filled cleft with cerebrospinal fluid that extends from the pial surface to the ventricle. There exists a paucity in scientific literature regarding the association between schizencephaly and psychosis. We report a case of a 36-year-old male, presented with worsening crisis of aggression, disorganized behavior and auditory hallucinations over 20 years. CT brain scan revealed unilateral left open lip schizencephaly, a finding during his recent admission to the psychiatry ward.

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Schizencephaly; Malformation; Psychosis

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