Lithium-induced Nephrogenic Diabetes Insipidus

Bee Zhen Ng, Chong Guan Ng, Sapini Yacob


Lithium is a unique agent that remains the gold standard among mood stabilizers. Nephrogenic diabetes insipidus is one of the most common adverse effects as a result of chronic lithium use. However, monitoring is understated and it is often identified by our medical counterparts in an acute setting. We herein report a case of undiagnosed nephrogenic diabetes insipidus in the context of lithium intoxication, brought to attention only following an acute medical condition. As a common medication prescribed by mental health practitioners, early detection of nephrogenic diabetes insipidus should be emphasized as it can lead to increased morbidity and mortality if not promptly identified and managed. Clinicians, especially in the psychiatric setting should actively enquire on the polyuria-polydipsia complex, and remain vigilant in the monitoring of serum sodium, urine output and osmolality.

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Lithium-induced nephrogenic diabetes insipidus; lithium intoxication

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